Notario A, Ricetti M, Trpin L, Doneda G, Zighelboim M
Minerva Med. 1978 Oct 17;69(49):3387-94.
Gastric juice proteins were studied in normal subjects and persons with gastro-intestinal, lung and pancreatic neoplasia and chronic systemic lymphopathy and haemoblastosis, using cellulose acetate and acrylamide gel electrophoresis of the freeze-dried dialyaste and chromatography of the amino acids obtained from the hydrolysate. Definite evidence was gathered of both qualitative and quantitative changes in protein fractions. Patterns varied from one group of subjects to another, though the basic picture was the same in both intestinal and extra-intestinal conditions. An effective relationship between the diseases considered is postulated and the data are interpreted with a view to evolving other points for further investigation.
利用冻干透析物的醋酸纤维素和丙烯酰胺凝胶电泳以及从水解产物中获得的氨基酸的色谱分析,对正常受试者以及患有胃肠道、肺部和胰腺肿瘤、慢性全身性淋巴病和血液病的患者的胃液蛋白质进行了研究。收集到了蛋白质组分定性和定量变化的确切证据。蛋白质图谱在不同组的受试者之间有所不同,尽管在肠道和肠道外疾病状态下基本情况是相同的。推测了所考虑疾病之间的有效关系,并对数据进行了解释,以期提出其他进一步研究的要点。