Czeizel A, Métneki J, Osztovics M
J Med Genet. 1981 Apr;18(2):91-8. doi: 10.1136/jmg.18.2.91.
The impact of information-guidance type of genetic counseling was evaluated for the family planning of 2082 consultands. The understanding of the risks, parental decision, and the number of induced and spontaneous abortions were evaluated by the use of questionnaires. The stillbirths, livebirths, infant deaths, and babies with inherited or congenital anomalies were checked by experts. When pregnancy was recommended the rate deterred was 4.7% while this rate was 61.7% and 60.7% when pregnancy was not recommended or pregnancy required consideration. When pregnancy was not recommended, 43.5% of offspring had congenital anomalies, while this value fitted with random risk (4%) in offspring born after recommended pregnancies.
对2082名咨询者的计划生育情况评估了信息指导型遗传咨询的影响。通过问卷调查评估了对风险的理解、父母的决定以及人工流产和自然流产的数量。由专家检查死产、活产、婴儿死亡以及患有遗传性或先天性异常的婴儿情况。当建议妊娠时，被劝阻的比例为4.7%，而当不建议妊娠或妊娠需要考虑时，这一比例分别为61.7%和60.7%。当不建议妊娠时，43.5%的后代有先天性异常，而这一数值与建议妊娠后出生的后代的随机风险（4%）相符。
