Czeizel A E, Intôdy Z, Modell B
Department of Human Genetics and Teratology, National Institute of Hygiene, Budapest, Hungary.
BMJ. 1993 Feb 20;306(6876):499-503. doi: 10.1136/bmj.306.6876.499.
To estimate the proportion of preventable congenital abnormalities in Hungary.
Analysis of available Hungarian data-bases and of the effectiveness of primary, secondary, and tertiary preventive methods.
Databases of ad hoc epidemiological studies and of the Hungarian congenital abnormality registry.
Prevalence at birth and prevalence after prevention in 73 congenital abnormality types or groups.
Preventive methods are available for 51 (70%) of the 73 congenital abnormality types or groups evaluated. The birth prevalence of all congenital abnormalities could be reduced from 65 to 26 per 1000; thus 39 per 1000 (60%) are preventable. Without congenital dislocation of the hip, which is unusually common in Hungary, the preventable proportion of congenital abnormalities is 52%.
Many congenital abnormalities can be prevented, but as they do not represent a single pathological category there is no single strategy for their prevention.
评估匈牙利可预防的先天性异常的比例。
分析匈牙利现有的数据库以及一级、二级和三级预防方法的有效性。
专门的流行病学研究数据库和匈牙利先天性异常登记处。
73种先天性异常类型或组的出生患病率及预防后的患病率。
在所评估的73种先天性异常类型或组中，有51种（70%）有预防方法。所有先天性异常的出生患病率可从每1000例65例降至26例；因此，每1000例中有39例（60%）是可预防的。若不考虑在匈牙利异常常见的先天性髋关节脱位，先天性异常的可预防比例为52%。
许多先天性异常是可以预防的，但由于它们并非单一的病理类别，因此没有单一的预防策略。
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