Mazzaferri E L
Postgrad Med. 1981 Jul;70(1):98-103. doi: 10.1080/00325481.1981.11715809.
The approach to management of an isolated thyroid nodule requires some understanding of the natural history of thyroid cancer and other forms of nodular thyroid disease. The histologic classification of thyroid cancer is an important determinant of survival, as are the size of the primary tumor, presence of thyroid capsule invasion, and presence of distant metastases. Therapeutic radiation and radioactive fallout increase the risk that a thyroid nodule is malignant. Autonomously functioning thyroid nodules are usually benign follicular adenomas and may cause thyrotoxicosis.
孤立性甲状腺结节的管理方法需要对甲状腺癌和其他形式的结节性甲状腺疾病的自然病史有所了解。甲状腺癌的组织学分类是生存的重要决定因素,原发肿瘤的大小、甲状腺包膜侵犯的存在以及远处转移的存在也是如此。治疗性辐射和放射性尘埃会增加甲状腺结节为恶性的风险。自主功能性甲状腺结节通常是良性滤泡性腺瘤,可能导致甲状腺毒症。