Improvement of post-heparin lipolytic activity (PHLA) after haemofiltration, in uraemic patients.

UNLABELLED

The decrease of serum PHLA in uraemic patients has been attributed to toxic effects of 'middle molecules' on lipoprotein lipase. Haemofiltration could improve PHLA by increasing 'middle molecule' clearance. Serum triglyceride concentration decreased and PHLA improved in three uraemic patients who received haemofiltration during three weeks as the initial treatment schedule. Activated PHLA of a healthy subject failed to be inhibited by uraemic sera and uraemic plasma ultrafiltrates obtained in vitro using polyacrylonitrile and cuprophane membranes.

CONCLUSION

haemofiltration is able to improve PHLA and to restore normal serum triglyceride concentrations. The reported toxicity of uraemic serum may affect metabolic steps preceding the activation of the circulating lipolytic enzymes.