Jörstad S, Smeby L C, Wideröe T E, Berg K J
Proc Eur Dial Transplant Assoc. 1979;16:212-7.
Based on earlier results which indicate that certain uraemic toxins (verified by an in vitro assay system) are larger than 10,000 daltons - a new system for treatment of endstage renal failure, SElective DUal Filtration ARtificial Kidney (SEDUFARK) has been developed. This system consists of a multimembrane filter/dialyser unit making removal of small molecules (mol wt less than 200) and substances in the mol wt range 10,000 - 40,000 possible without exchange of body fluids. Evaluation of pre and post treatment uraemic plasma with the bio assay showed that SEDUFARK was superior to conventional haemofiltration (CHF) with polyacrylonitrile (PAN) or Gambro Lundia Major High Flux 1.36 m2 (CPN) membranes as filters.
基于早期结果表明某些尿毒症毒素（经体外检测系统验证）分子量大于10000道尔顿，一种用于终末期肾衰竭治疗的新系统——选择性双重过滤人工肾（SEDUFARK）已被开发出来。该系统由一个多膜过滤器/透析器单元组成，能够在不进行体液交换的情况下清除小分子（分子量小于200）以及分子量在10000 - 40000范围内的物质。通过生物检测对尿毒症血浆治疗前后进行评估显示，SEDUFARK比使用聚丙烯腈（PAN）或金宝Lundia Major高通量1.36平方米（CPN）膜作为过滤器的传统血液滤过（CHF）更具优势。
