Mueller U W, Potter J M
Res Commun Chem Pathol Pharmacol. 1981 May;32(2):195-206.
In the present study human equivalent doses of the synthetic glucocorticoid, prednisolone, were administered intravenously into male rats. The prednisolone was rapidly cleared from blood and accumulated in the liver, from where it and metabolized prednisolone was excreted into the small intestine after a short time. By cannulation of the common bile duct with serial collection of bile it was shown that liver was able to handle relatively large doses of the steroid. There was good evidence of an enterohepatic circulation of steroid with relationships of time and content of prednisolone in liver and small intestine.
在本研究中，将合成糖皮质激素泼尼松龙的等效人用剂量静脉注射到雄性大鼠体内。泼尼松龙迅速从血液中清除并在肝脏中蓄积，短时间后它及其代谢产物泼尼松龙从肝脏排泄到小肠。通过插管胆总管并连续收集胆汁表明，肝脏能够处理相对大剂量的该类固醇。有充分证据表明类固醇存在肠肝循环，且肝脏和小肠中泼尼松龙的时间和含量之间存在关联。
