Confavreux C, Mauguière F, Courjon J, Aimard G, Devic M
Rev Neurol (Paris). 1981;137(2):121-32.
25 Multiple Sclerosis patients had Visual Evoked Potentials (VEPs) recorded at a one year interval. Abnormal VEPs were observed at least once in 21 patients. They were the only means to assess the lesional dissemination in 9 patients. Their contribution in the diagnostic classification is such that the proportion of "definite" cases rises from 44 to 80 per cent of the 25 cases. The degree of abnormality of the VEPs had no relation to the disability status and the whole severity of the disease. The main feature ws the variability of the VEP latencies at a one year interval: they seem to follow the remittent progressive course of the disease, whether visual pathways are clinically affected or not. These results are interpreted in the light of the pathophysiological data of the disease. In the cases with improvement or normalisation of the second VEPs, "en plaque" edema may be an important mechanism, sometimes free of demyelination so that true restitutio ad integrum may occur.
25例多发性硬化症患者每隔一年记录一次视觉诱发电位（VEP）。21例患者至少有一次观察到异常VEP。在9例患者中，它们是评估病变扩散的唯一手段。它们在诊断分类中的作用使得“确诊”病例的比例从25例中的44%上升到80%。VEP的异常程度与残疾状况和疾病的整体严重程度无关。主要特征是VEP潜伏期在一年间隔内的变异性：无论视觉通路是否受到临床影响，它们似乎都遵循疾病的缓解进展过程。这些结果根据该疾病的病理生理数据进行了解释。在第二次VEP改善或恢复正常的病例中，“斑块内”水肿可能是一个重要机制，有时没有脱髓鞘，因此可能会真正恢复正常。
