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人类骨痛病的随访研究。第二部分:专项调查。

Human neurolathyrism, a follow-up study. Part II: Special investigations.

作者信息

Cohn D F, Streifler M

出版信息

Schweiz Arch Neurol Neurochir Psychiatr. 1981;128(1):157-63.

PMID:7244574
Abstract

Special investigations were undertaken in the group of patients suffering from chronic neurolathyrism as described in part one of our work. X-ray films of the skeleton were taken of 45 patients. Pathologic findings similar to experimental osteolathyrism were revealed in 5 patients. These observations have not been described before. Sural nerve biopsies were taken from three patients with lathyric sensory neuropathy. Electron microscopy revealed mainly thick myelin sheaths which extended into the axonal regions. The picture is similar to the "tomaculous" neuropathy of Bradley. The lower motor neuron was involved in a few cases, manifested by delayed nerve conduction time and muscular atrophies.

摘要

在我们研究的第一部分所描述的慢性神经型山黧豆中毒患者组中进行了专项调查。对45例患者进行了骨骼X光片检查。在5例患者中发现了与实验性骨山黧豆中毒相似的病理表现。这些观察结果此前未曾有过描述。对3例患有山黧豆中毒性感觉神经病变的患者进行了腓肠神经活检。电子显微镜检查主要显示增厚的髓鞘延伸至轴突区域。这一表现与布拉德利的“腊肠样”神经病变相似。少数病例中累及下运动神经元,表现为神经传导时间延迟和肌肉萎缩。

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