在人体中，磺吡酮（安妥明）对离体花生四烯酸钠诱导的血小板聚集和丙二醛（MDA）生成具有长期抑制作用。 - Suppr

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超能文献

Prolonged inhibition of ex vivo sodium arachidonate-induced platelet aggregation and malondialdehyde (MDA) production by sulphinpyrazone (Anturan) in man.

作者信息

Maguire E D, Pay G F, Wallis R B, White A M

出版信息

Thromb Res. 1981 Feb 1;21(3):321-7. doi: 10.1016/0049-3848(81)90170-5.

DOI:10.1016/0049-3848(81)90170-5

PMID:7245142

Abstract

摘要

相似文献

Prolonged inhibition of ex vivo sodium arachidonate-induced platelet aggregation and malondialdehyde (MDA) production by sulphinpyrazone (Anturan) in man.在人体中，磺吡酮（安妥明）对离体花生四烯酸钠诱导的血小板聚集和丙二醛（MDA）生成具有长期抑制作用。

Thromb Res. 1981 Feb 1;21(3):321-7. doi: 10.1016/0049-3848(81)90170-5.

The effect of sulphinpyrazone and its metabolites on platelet function in vitro and ex vivo.磺吡酮及其代谢产物对体外和体内血小板功能的影响。

Haemostasis. 1981;10(3):165-75. doi: 10.1159/000214400.

The effects of two different dosage regimens of sulphinpyrazone on platelet function ex vivo and blood chemistry in man.

Haemostasis. 1981;10(3):153-64. doi: 10.1159/000214399.

A metabolite of sulphinpyrazone that is largely responsible for the effect of the drug on the platelet prostaglandin pathway.磺吡酮的一种代谢产物，它在很大程度上决定了该药物对血小板前列腺素途径的作用。

Biochem Soc Trans. 1980 Dec;8(6):727-8. doi: 10.1042/bst0080727.

A study of the relationship between ex vivo and in vivo effects of sulphinpyrazone in the guinea pig.关于磺吡酮在豚鼠体内外效应之间关系的研究。

Haemostasis. 1979;8(3-5):353-60. doi: 10.1159/000214325.

Measurement of malonyldialdehyde production during sodium arachidonate-induced polymorphonuclear leukocyte aggregation.花生四烯酸钠诱导多形核白细胞聚集过程中丙二醛生成量的测定。

J Pharmacol Methods. 1985 Apr;13(2):179-86. doi: 10.1016/0160-5402(85)90061-0.

Indobufen treatment in type IIA hypercholesterolemic subjects: effects on platelet function and malondialdehyde production.吲哚布芬对IIA型高胆固醇血症患者的治疗：对血小板功能和丙二醛生成的影响。

Pharmacol Res Commun. 1981 Oct;13(9):847-59. doi: 10.1016/s0031-6989(81)80045-8.

Inhibition of human platelet cyclo-oxygenase activity by sulfinpyrazone and three of its metabolites.磺吡酮及其三种代谢产物对人血小板环氧化酶活性的抑制作用。

Eur J Pharmacol. 1984 Jun 1;101(3-4):209-14. doi: 10.1016/0014-2999(84)90158-4.

Correlation between inhibitory effect on platelet aggregation and disposition of sulfinpyrazone and its metabolites in rabbits. Part I: Single dose study.

Biopharm Drug Dispos. 1987 Jan-Feb;8(1):1-9. doi: 10.1002/bdd.2510080102.

Inhibition by sulphinpyrazone of the platelet-dependent bronchoconstriction due to platelet-activating factor (PAF-acether) in the guinea pig.在豚鼠中，磺吡酮对血小板活化因子（PAF-乙酰醚）所致的血小板依赖性支气管收缩的抑制作用。

Eur J Pharmacol. 1982 Feb 19;78(1):71-9. doi: 10.1016/0014-2999(82)90373-9.

引用本文的文献

Pharmacokinetics and Reversible Biotransformation of Sulfinpyrazone and Its Metabolites in Rabbits. II. Multiple-Dose Study.磺胺吡嗪及其代谢物在兔体内的药代动力学和可还原生物转化。二。多次给药研究。

Pharm Res. 1986 Jun;3(3):178-83. doi: 10.1023/A:1016322326443.

Pharmacokinetics and reversible biotransformation of sulfinpyrazone and its metabolites in rabbits. I. Single-dose study.磺胺吡嗪及其代谢物在兔体内的药代动力学和可还原生物转化。I. 单剂量研究。

Pharm Res. 1986 Jun;3(3):173-7. doi: 10.1023/A:1016370209604.

Plasma levels of sulfinpyrazone and of two of its metabolites after a single dose and during the steady state.单次给药后及稳态期间苯磺唑酮及其两种代谢物的血浆水平。

Eur J Clin Pharmacol. 1983;24(2):231-5. doi: 10.1007/BF00613823.

Pharmacokinetics of sulphinpyrazone and its major metabolites after a single dose and during chronic treatment.单次给药及长期治疗后磺吡酮及其主要代谢产物的药代动力学

Eur J Clin Pharmacol. 1985;28(1):97-103. doi: 10.1007/BF00635715.

Arachidonic acid-induced platelet aggregation and prostanoid formation in whole blood in relation to plasma concentration of indomethacin.花生四烯酸诱导的全血中血小板聚集和类前列腺素生成与血浆中吲哚美辛浓度的关系

Eur J Clin Pharmacol. 1985;28(2):163-9. doi: 10.1007/BF00609686.

A serial study of platelet reactivity throughout the first six months after myocardial infarction: its modification by sulphinpyrazone.心肌梗死后前六个月血小板反应性的系列研究：磺吡酮对其的影响

Postgrad Med J. 1987 May;63(739):351-6. doi: 10.1136/pgmj.63.739.351.

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