钼和铜对大鼠肾脏关键酶的影响，特别提及生理拮抗作用。

Effect of molybdenum and copper on key enzymes of rat kidney with special reference to physiological antagonism.

作者信息

Rana S V, Kumar A

出版信息

Toxicol Lett. 1981 Mar;7(6):393-7. doi: 10.1016/0378-4274(81)90083-7.

Abstract

Enzymological data on alkaline phosphatase, acid phosphatase, glucose-6-phosphatase, cholinesterase and lipase obtained in the kidney of rats, fed on molybdenum (Mo) and copper (Cu), are reported. Antagonistic or synergistic behaviour has been determined by feeding the rats simultaneously on these two metals. Molybdenum inhibited all other enzymes except acid phosphatase and lipase. Complete inhibition of alkaline phosphatase was recorded after copper treatment. The combined treatment with molybdenum and copper exhibited reversible enzyme changes, however, cholinesterase activity remained inhibited.

摘要

报道了在以钼（Mo）和铜（Cu）喂养的大鼠肾脏中获得的碱性磷酸酶、酸性磷酸酶、葡萄糖-6-磷酸酶、胆碱酯酶和脂肪酶的酶学数据。通过同时用这两种金属喂养大鼠来确定拮抗或协同行为。钼抑制了除酸性磷酸酶和脂肪酶之外的所有其他酶。铜处理后记录到碱性磷酸酶完全被抑制。钼和铜联合处理呈现出可逆的酶变化，然而，胆碱酯酶活性仍被抑制。