Denisov L E, Ermolaeva E V, Iarygin L M, Nikiforov A M
Vopr Onkol. 1981;27(5):14-7.
The results of evaluation of treatment of 98 breast cancer patients with bone metastases are presented. Metastases appeared 6 months -- 15 years after treatment; on the average, they appeared 20.2 months after treatment. Patients received complex therapy -- radiation and medication. The results of treatment were assessed on the basis of subjective (abatement or cessation of pain) and objective (bone reparation) criteria. Objective effect was observed in 4%, subjective one -- in 68.3% of cases. Apart from survival time and remission, the results of treatment were evaluated on the basis of the duration of painless period expressed by means of "no-pain index" -- the ratio of the painless period duration to survival time which elapsed since skeletal metastasis detection, multiplied by 100. The study showed that complex therapy has a considerable palliative effect in some cases -- abatement or cessation of pain for over 54--60% of the survival time of patients.
本文介绍了98例乳腺癌骨转移患者的治疗评估结果。转移发生在治疗后6个月至15年；平均而言，转移出现在治疗后20.2个月。患者接受了综合治疗——放疗和药物治疗。治疗结果根据主观（疼痛减轻或停止）和客观（骨修复）标准进行评估。4%的病例观察到客观效果，68.3%的病例观察到主观效果。除了生存时间和缓解情况外，治疗结果还根据通过“无痛指数”表示的无痛期持续时间进行评估——无痛期持续时间与自骨骼转移检测以来所经历的生存时间之比，再乘以100。研究表明，综合治疗在某些情况下具有相当大的姑息作用——在患者超过54%至60%的生存时间内疼痛减轻或停止。
