Kolygin B A, Evtiukhin A I, Gol'zand I V
Vopr Onkol. 1981;27(5):49-54.
The effects of different kinds of anesthesia on the function of live (evaluated on the basis of activity of enzymes -- aspartate aminotransferase, fructose-I-monophosphate aldelase and glutamate dehydrogenase) were studied in 63 infantile patients with Hodgkin's disease who underwent diagnostic laparotomy with splenectomy. It was found that during the first 6 days after surgery, the rate of activity of these enzymes shows a rise and reaches the upper limits in 77.8% of cases. Halothane anesthesia induced excessive enzymatic activity in 100%, while neuroleptanalgesia -- in 53.8% of cases. Repeated application of halothane produced a higher hepatotoxic effect as manifested by enhanced activity of glutamate dehydrogenase on days 1--2 after operation.
对63例接受诊断性剖腹脾切除术的霍奇金病患儿，研究了不同麻醉方式对肝脏功能（根据天冬氨酸转氨酶、果糖 - 1 - 磷酸醛缩酶和谷氨酸脱氢酶的活性进行评估）的影响。结果发现，术后前6天，这些酶的活性速率呈上升趋势，77.8%的病例达到上限。氟烷麻醉100%导致酶活性过高，而神经安定镇痛麻醉则在53.8%的病例中出现这种情况。重复使用氟烷会产生更高的肝毒性作用，表现为术后第1 - 2天谷氨酸脱氢酶活性增强。
