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对注射木糖醇和葡萄糖的大鼠组织中C2有机酸的体内研究。

In-vivo studies on C2 organic acids in the tissues of rats injected with xylitol and glucose.

作者信息

Hauschildt S, Chalmers R A, Lawson A M, Brand K

出版信息

Z Ernahrungswiss. 1981 Mar;20(1):69-75. doi: 10.1007/BF02027959.

DOI:10.1007/BF02027959
PMID:7245807
Abstract

Oxalic, glyoxylic, and glycollic acid were determined in rat liver and kidney after injection with [U-14C]-xylitol or [U-14C]-glucose. Neither glucose nor xylitol led to the formation of oxalic and glyoxylic acid, yet glycollic acid was found in both tissues after injection with xylitol. Possible pathways leading from xylitol to glycollic acid are discussed.

摘要

在给大鼠注射[U-14C]-木糖醇或[U-14C]-葡萄糖后，测定了大鼠肝脏和肾脏中的草酸、乙醛酸和乙醇酸。葡萄糖和木糖醇均未导致草酸和乙醛酸的形成，但在注射木糖醇后，两种组织中均发现了乙醇酸。本文讨论了从木糖醇生成乙醇酸的可能途径。

相似文献

1
In-vivo studies on C2 organic acids in the tissues of rats injected with xylitol and glucose.对注射木糖醇和葡萄糖的大鼠组织中C2有机酸的体内研究。
Z Ernahrungswiss. 1981 Mar;20(1):69-75. doi: 10.1007/BF02027959.
2
[14C]oxalate synthesis from [U-14C]glyoxylate and [1-14C]glycollate in isolated rat hepatocytes.在分离的大鼠肝细胞中由[U-14C]乙醛酸和[1-14C]乙醇酸合成[14C]草酸盐
Biochem Med. 1976 Dec;16(3):277-83. doi: 10.1016/0006-2944(76)90033-8.
3
[14C]oxalate formation from [U-14C]glucose and [U-14C]xylitol in isolated rat hepatocytes.
Nihon Jinzo Gakkai Shi. 1983 Sep;25(9):1079-82.
4
The production of (14C) oxalate during the metabolism of (14C) carbohydrates in isolated rat hepatocytes.在分离的大鼠肝细胞中，（14C）碳水化合物代谢过程中（14C）草酸盐的生成。
Aust J Exp Biol Med Sci. 1980 Apr;58(2):103-16. doi: 10.1038/icb.1980.10.
5
[14C]oxalate formation from [U-14C]glucose and [U-14C]xylitol in rat liver homogenate.大鼠肝脏匀浆中由[U-14C]葡萄糖和[U-14C]木糖醇生成[14C]草酸盐
Biochem Med. 1979 Feb;21(1):55-61. doi: 10.1016/0006-2944(79)90055-3.
6
Comparison of xylitol and glucose metabolism in nonhepatic rat tissues.非肝脏大鼠组织中木糖醇与葡萄糖代谢的比较
Z Ernahrungswiss. 1976 Dec;15(4):345-54. doi: 10.1007/BF02020503.
7
Conversion of [U-13C]xylitol and D-[U-13C]glucose into urinary [1,2-13C]glycollate and [1,2-13C]oxalate in man.
Int J Vitam Nutr Res Suppl. 1985;28:119-33.
8
The urinary excretion of glycollic acid and threonic acid by xylitol-infused patients and their relationship to the possible role of 'active glycoladehyde' in the transketolase reaction in vivo.木糖醇输注患者的乙醇酸和苏糖酸的尿排泄及其与“活性乙醇醛”在体内转酮醇酶反应中可能作用的关系。
Biochem Soc Trans. 1975;3(4):518-21. doi: 10.1042/bst0030518.
9
Oxalate synthesis from [14C1]glycollate and [14C1]glyoxylate in the hepatectomized rat.肝切除大鼠中由[14C1]乙醇酸和[14C1]乙醛酸合成草酸盐的过程。
Biochim Biophys Acta. 1983 May 4;757(1):8-14. doi: 10.1016/0304-4165(83)90146-0.
10
Xylitol infusion and oxalate formation in rabbits.
J Nutr. 1977 May;107(5):792-804. doi: 10.1093/jn/107.5.792.

本文引用的文献

1
Enzymatic oxalate determination in urine.尿液中草酸的酶法测定
Clin Chem. 1963 Jun;9:334-9.
2
The conversion of [1-13C]glycine and [2-13C]glycine to [13C]oxalate in primary hyperoxaluria: evidence for the existence of more than one metabolic pathway from glycine to oxalate in man.原发性高草酸尿症中[1-¹³C]甘氨酸和[2-¹³C]甘氨酸向[¹³C]草酸盐的转化：人体中存在不止一条从甘氨酸到草酸盐代谢途径的证据。
Clin Sci. 1968 Oct;35(2):325-35.
3
[The metabolism of xylitol in normal and alloxan diabetic rabbits].[正常及四氧嘧啶糖尿病兔体内木糖醇的代谢]
Z Gesamte Exp Med Einschl Exp Chir. 1967;142(4):338-50.
4
Disorders of oxalate metabolism.
Am J Med. 1968 Nov;45(5):715-35. doi: 10.1016/0002-9343(68)90207-6.
5
Lactate and pyruvate metabolism and reducing equivalent transfer in Ehrlich ascites tumor.艾氏腹水瘤中的乳酸和丙酮酸代谢以及还原当量转移
Cancer Res. 1974 Apr;34(4):872-7.
6
The quantitative extraction and gas-liquid chromatographic determination of organic acids in urine.尿液中有机酸的定量提取及气液色谱测定
Analyst. 1972 Dec;97(161):958-67. doi: 10.1039/an9729700958.
7
Complications following intravenous administration of solutions containing xylitol.
Med J Aust. 1972 Jun 10;1(24):1238-46. doi: 10.5694/j.1326-5377.1972.tb116530.x.
8
Oxalate metabolism. I.草酸盐代谢。I.
Am J Clin Nutr. 1973 Jul;26(7):758-65. doi: 10.1093/ajcn/26.6.758.
9
[Therapeutically induced form of reno-cerebral oxalosis? (author's transl)].治疗性诱导的肾脑草酸沉积症？（作者译）
Acta Neuropathol. 1974 Feb 28;27(2):181-4. doi: 10.1007/BF00687169.
10
[Enzymatic endpoint determination of xylitol (author's transl)].木糖醇的酶促终点测定（作者译）
Z Klin Chem Klin Biochem. 1973 Dec;11(12):535-6.