Hackel D B, Mikat E M, Reimer K, Whalen G
Am J Physiol. 1981 Jul;241(1):H12-7. doi: 10.1152/ajpheart.1981.241.1.H12.
Myocardial blood flow and left ventricular oxygen utilization were studied in verapamil-treated and untreated pentobarbital-anesthetized dogs subjected to hemorrhagic shock. Blood loss was similar in both groups. The dogs treated with verapamil (n = 15) during shock had a slower heart rate and lower left ventricular oxygen utilization than the untreated dogs (n = 14). Nevertheless, the treated dogs had a significantly higher myocardial blood flow and were able to maintain a higher cardiac index. Thus, verapamil has beneficial hemodynamic and metabolic effects that preserve myocardial function. These effects may explain the improved survival and protection of the heart against anatomic lesions, which have been demonstrated previously in dogs treated with verapamil during hemorrhagic shock.
在戊巴比妥麻醉下，对经维拉帕米治疗和未经治疗的失血性休克犬的心肌血流和左心室氧利用情况进行了研究。两组的失血量相似。休克期间接受维拉帕米治疗的犬（n = 15）心率较慢，左心室氧利用低于未治疗的犬（n = 14）。然而，接受治疗的犬心肌血流显著更高，并且能够维持更高的心指数。因此，维拉帕米具有有益的血流动力学和代谢作用，可保护心肌功能。这些作用可能解释了在失血性休克期间接受维拉帕米治疗的犬生存率提高以及心脏免受解剖学损伤，这一点先前已得到证实。
