Garan H, Ruskin J N, Powell W J
Am J Physiol. 1981 Jul;241(1):H67-72. doi: 10.1152/ajpheart.1981.241.1.H67.
Studies on the efficacy of phenytoin administered directly into the cerebrospinal fluid in protecting against digoxin-induced arrhythmias were carried out in 20 anesthetized dogs. Phenytoin was administered in an average dose of 10 mg directly into the cisterna magna of 10 dogs. The other control dogs received only the vehicle for phenytoin intrathecally. Both groups of dogs subsequently received a toxic dose of digoxin (0.2 mg/kg) intravenously. The time after intravenous digoxin to the onset of ventricular premature beats, ventricular tachycardia and ventricular fibrillation (VF) was significantly shorter in control animals compared to the phenytoin-treated dogs. In the control group, one dog survived the 3-h observation period without developing ventricular fibrillation, whereas 5 of the 10 phenytoin-treated dogs survived this period without VF (P less than 0.05). Phenytoin had a similar protective effect against digoxin-induced arrhythmias in 10 other dogs that received phenytoin intravenously. In the animals that received phenytoin intrathecally, plasma concentrations of phenytoin were undetectable. Thus, in this experimental model, phenytoin exerts a protective effect against digoxin-induced ventricular arrhythmias which is mediated via the central nervous system.
在20只麻醉犬身上进行了关于直接向脑脊液中注入苯妥英钠预防地高辛诱导的心律失常疗效的研究。给10只犬经枕大池平均直接注入10毫克苯妥英钠。其他对照犬鞘内仅注入苯妥英钠的赋形剂。两组犬随后均静脉注射中毒剂量的地高辛（0.2毫克/千克）。与苯妥英钠治疗的犬相比，对照动物静脉注射地高辛后出现室性早搏、室性心动过速和心室颤动（VF）的时间明显更短。在对照组中，1只犬在3小时观察期内存活且未发生心室颤动，而10只接受苯妥英钠治疗的犬中有5只在此期间存活且未发生VF（P小于0.05）。苯妥英钠对另外10只静脉注射苯妥英钠的犬的地高辛诱导的心律失常也有类似的保护作用。在鞘内注射苯妥英钠的动物中，未检测到苯妥英钠的血浆浓度。因此，在该实验模型中，苯妥英钠对由地高辛诱导的室性心律失常具有保护作用，这种作用是通过中枢神经系统介导的。
