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离体灌注豚鼠胎盘的血管容积

Vascular volumes in isolated perfused guinea pig placenta.

作者信息

Schröder H, Paul W, Leichtweiss H P

出版信息

Am J Physiol. 1981 Jul;241(1):H73-7. doi: 10.1152/ajpheart.1981.241.1.H73.

DOI:10.1152/ajpheart.1981.241.1.H73
PMID:7246791
Abstract

Maternal and fetal vascular volumes were determined in 13 isolated artificially perfused guinea pig placentas by measuring mean transit times of an intravascular indicator (Evan's blue dye) at constant flow rates. When both maternal and fetal flow rates were 3.1 ml/min, the average maternal volume of the placenta was 1.85 +/- 0.54 (SD) ml, and the mean fetal volume was 0.92 +/- 0.2 (SD) ml. If calculated maternal volumes were corrected for the myometrial vascular volume and for the interlobium volume, the remaining volume attributable largely to the labyrinth averaged approximately 1.2 ml. When flow rates were changed on the fetal or the maternal side between 0 and 6.2 ml/min, vascular volumes also changed. For example, volumes increased directly with flow rates on that side of the placenta in which the flow change was introduced; in most cases, it decreased on the opposite side where the flow rates had not been altered. This intraplacental volume shift may be regarded as the basic event for the sluice flow phenomenon in placentas.

摘要

通过在恒定流速下测量血管内指示剂(伊文思蓝染料)的平均通过时间,对13个分离的人工灌注豚鼠胎盘的母体和胎儿血管容积进行了测定。当母体和胎儿流速均为3.1毫升/分钟时,胎盘的平均母体容积为1.85±0.54(标准差)毫升,平均胎儿容积为0.92±0.2(标准差)毫升。如果对计算出的母体容积进行子宫肌层血管容积和叶间容积的校正,那么主要归因于迷路的剩余容积平均约为1.2毫升。当胎儿侧或母体侧的流速在0至6.2毫升/分钟之间变化时,血管容积也会改变。例如,在引入流速变化的胎盘那一侧,容积随流速直接增加;在大多数情况下,在流速未改变的对侧容积会减少。这种胎盘内的容积转移可被视为胎盘中闸流现象的基本事件。

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