Grant S
Ann Ophthalmol. 1981 Feb;13(2):209-11.
Probenecid was given intravenously to rabbits in an effort to extend the intraocular longevity of intravitreal methicillin. With relatively high levels of probenecid, an insignificant elevation of half-life was obtained. Aqueous levels of methicillin were measured after intravitreal injection and were found to be adequate to inhibit penicillinase-producing S. aureus for approximately 20 hours.
为了延长玻璃体内注射甲氧西林在眼内的存留时间，给兔子静脉注射丙磺舒。使用相对较高剂量的丙磺舒时，半衰期仅有微不足道的延长。在玻璃体内注射后测量了房水中甲氧西林的水平，发现其足以抑制产青霉素酶的金黄色葡萄球菌约20小时。
