Singham K T, Anuar M, Puthucheary S D
Ann Acad Med Singap. 1980 Oct;9(4):435-9.
The clinical pattern of infective endocarditis as seen in 101 patients at the University Hospital in Kuala Lumpur from 1968 to 1977 is reviewed. There were 60 males and 41 females. Majority of the patients were between 10-40 years of age. The most frequent underlying heart disease was rheumatic valvular disease (69%). Endocarditis was most frequent when aortic and mitral valve disease co-existed. Other than one patient who had candida endocarditis on a Bjork Shiley valve, the other patients had congenital heart disease. Patent ductus arteriosus was the commonest congenital heart disease. Microorganisms were identified in 77 patients. Streptococcus species was the commonest, followed by streptococcus aureus. The clinical features included fever, splenomegaly, petechial haemorrhages, finger clubbing, heart failure, peripheral and pulmonary emboli and neurological lesions. On adequate antibiotic therapy the hospital mortality was 22.7%. Most of the deaths were due to major cardiac or neurological complications.
本文回顾了1968年至1977年在吉隆坡大学医院就诊的101例感染性心内膜炎患者的临床情况。其中男性60例，女性41例。大多数患者年龄在10至40岁之间。最常见的基础心脏病是风湿性瓣膜病（69%）。当主动脉瓣和二尖瓣疾病同时存在时，心内膜炎最为常见。除1例在Bjork Shiley瓣膜上发生念珠菌性心内膜炎的患者外，其他患者均患有先天性心脏病。动脉导管未闭是最常见的先天性心脏病。77例患者中鉴定出了微生物。链球菌是最常见的，其次是金黄色葡萄球菌。临床特征包括发热、脾肿大、瘀点出血、杵状指、心力衰竭、外周和肺部栓塞以及神经病变。经充分的抗生素治疗后，医院死亡率为22.7%。大多数死亡是由于严重的心脏或神经并发症。
