Taguchi K, Matsummura M, Kawaue Y, Nakagaki M, Mochizuki T
Artif Organs. 1981 Feb;5(1):33-7.
This study was designed to extend the clinical indications of ventricular bypass to infants and newborns with severe left ventricular failure. The circuit is composed of 8-mm polyvinyl chloride tubing, microfilter, local heparinization circuit, and outflow-withdrawal cannulas of 10F to 20F. Filling capacity is 150-270 ml. In acute nonpulsatile left ventricular bypass experiments using six dogs weighing 3-7 kg, a bypass equivalent to 100% of the cardiac output prior to bypass could be attained in both normal and induced failure model of heart. Through left ventricular bypass the effects of left ventricular support such as marked reduction of LVP, LVmax dp/dt, and TTI were observed.
本研究旨在将心室旁路的临床适应症扩展至患有严重左心室衰竭的婴儿和新生儿。该回路由8毫米聚氯乙烯管、微滤器、局部肝素化回路以及10F至20F的流出-引出插管组成。容量为150 - 270毫升。在使用6只体重3 - 7千克的犬进行的急性非搏动性左心室旁路实验中，在正常和诱导性心力衰竭模型中均可实现相当于旁路前心输出量100%的旁路。通过左心室旁路，观察到了左心室支持的效果，如左心室压力（LVP）、左心室最大dp/dt和张力-时间指数（TTI）显著降低。
