Severe meprobamate intoxication treated by hemoperfusion over amberlite resin.

A 36-year-old female was treated successfully by hemoperfusion over Amberlite XAD-4 resin after ingestion of 40 gm of meprobamate. Hemoperfusion was started five hours after the ingestion. At that time the patient was in deep coma. The patient was treated by hemoperfusion for five hours, at the end of which time she was awake. Meprobamate clearance over the resin was about 290 mg/min. There were no bleeding complications. It is concluded that hemoperfusion over amberlite XAD-4 resin is a highly effective method in the treatment of severe cases of meprobamate intoxication.