Prinzen F W, van der Vusse G J, Coumans W A, Kruger R, Verlaan C W, Reneman R S
Basic Res Cardiol. 1981 Mar-Apr;76(2):197-210. doi: 10.1007/BF01907958.
In the present investigation the effect of elevated arterial free fatty acid (FFA) concentrations on regional myocardial blood flow (MBF), myocardial metabolism and hemodynamics during ischemia was studied in anesthetized dogs. Ischemia was induced by stenosis of the left interventricular coronary artery. Mean poststenotic coronary artery pressure was kept constant during ischemia. FFA concentrations were elevated by intravenous injection of heparin (group I), intralipid (group II) or both substances (group III). After elevation of FFA concentrations by heparin alone or together with intralipid, heart rate gradually increased, while aortic pressure tended to decrease. Slight elevation of arterial FFA levels (up to 0.30 mM, group I, and up to 0.53 mM, group II) had no significant effect on total MBF and uptake of glucose, FFA, and oxygen or release of lactate in the ischemic myocardium. However, elevating arterial FFA levels up to 0.81 mM (Group III), significantly decreased total MBF (6%), endo/epicardial blood flow ratio (13%), and oxygen uptake (34%) in the ischemic myocardium and resulted in release of lactate from this area. The release of potassium, inorganic phosphate and H+ as well as plasma CO2 concentration were not influenced. Neither was the uptake of glucose and FFA. These findings suggest that elevated arterial FFA concentrations can decrease MBF and augment lactate production in the ischemic myocardium.
在本研究中，在麻醉犬身上研究了动脉游离脂肪酸（FFA）浓度升高对缺血期间局部心肌血流量（MBF）、心肌代谢和血流动力学的影响。通过左心室冠状动脉狭窄诱导缺血。缺血期间，狭窄后冠状动脉平均压力保持恒定。通过静脉注射肝素（I组）、脂质乳剂（II组）或两种物质（III组）来升高FFA浓度。单独使用肝素或与脂质乳剂一起升高FFA浓度后，心率逐渐增加，而主动脉压力有下降趋势。动脉FFA水平轻度升高（I组高达0.30 mM，II组高达0.53 mM）对缺血心肌的总MBF以及葡萄糖、FFA和氧气的摄取或乳酸的释放没有显著影响。然而，将动脉FFA水平升高至0.81 mM（III组），显著降低了缺血心肌的总MBF（6%）、心内膜/心外膜血流比值（13%）和氧气摄取（34%），并导致该区域乳酸释放。钾、无机磷酸盐和H+的释放以及血浆CO2浓度均未受影响。葡萄糖和FFA的摄取也未受影响。这些发现表明，动脉FFA浓度升高可降低缺血心肌的MBF并增加乳酸生成。
