Cane R D, Harrison R A, Shapiro B A, Kavanaugh J
Anesthesiology. 1980 Jul;53(1):53-5. doi: 10.1097/00000542-198007000-00010.
The spectral absorbance of Intralipid, a phospholipid emulsion, was investigated to discern its effect, when parenterally administered, on the spectrophotometric measurement of hemoglobin (Hb), oxyhemoglobin (HbO2), and carboxyhemoglobin (HbCO). While accounting for dilutional factors, various concentrations of Intralipid in both water and hemoglobin solutions were analyzed at six wavelengths commonly used to measure Hb, HbO2 and HbCO. Absorbance increased linearly with Intralipid concentration at all wavelengths, and ranged from 0.034 at 505 nm to 0.019 at 626.6 nm per mg of Intralipid. Therefore, in patients receiving Intralipid, significant errors in Hb, HbO2 and HbCO measurements can be introduced if these measurements are made by oximetry, and the authors suggest that such measurements should be accomplished by methods other than spectrophotometry.
研究了磷脂乳剂英脱利匹特（Intralipid）的光谱吸光度，以了解其经肠胃外给药后对血红蛋白（Hb）、氧合血红蛋白（HbO2）和碳氧血红蛋白（HbCO）分光光度测量的影响。在考虑稀释因素的情况下，对水和血红蛋白溶液中不同浓度的英脱利匹特在常用于测量Hb、HbO2和HbCO的六个波长处进行了分析。在所有波长下，吸光度均随英脱利匹特浓度呈线性增加，每毫克英脱利匹特的吸光度范围为505nm处为0.034至626.6nm处为0.019。因此，对于接受英脱利匹特治疗的患者，如果通过血氧测定法进行Hb、HbO2和HbCO测量，可能会引入显著误差，作者建议此类测量应采用分光光度法以外的方法完成。
