Seyfried T N, Yu R K
Biochem Genet. 1980 Dec;18(11-12):1229-37. doi: 10.1007/BF00484350.
Biochemical evidence of heterosis (hybrid vigor) for brain myelin content is presented. The concentrations of cerebroside and GM1 ganglioside, two glycolipids known to be abundant in myelin, were higher in the brains of (C57BL/6J X DBA/2J) F1 hybrids than in the brains of either parental strain. Furthermore, brain water content, which is known to be inversely related to myelin content, was lower in the F1 hybrids, especially during the most active period of myelin synthesis. Heterosis was not observed, however, for total brain ganglioside concentration. Additionally, the results do not substantiate a direct developmental-genetic relationship between brain myelin content and susceptibility to audiogenic seizures.
本文提供了脑髓磷脂含量杂种优势（杂交活力）的生化证据。已知在髓磷脂中含量丰富的两种糖脂——脑苷脂和GM1神经节苷脂，在（C57BL/6J×DBA/2J）F1杂种小鼠脑中的浓度高于任一亲本品系小鼠脑内的浓度。此外，已知与髓磷脂含量呈负相关的脑含水量，在F1杂种小鼠中较低，尤其是在髓磷脂合成最活跃的时期。然而，并未观察到全脑神经节苷脂浓度存在杂种优势。此外，研究结果并未证实脑髓磷脂含量与听源性癫痫易感性之间存在直接的发育遗传关系。
