Loscalzo B, Agrusta A, Agrusta M, Cerciello A, Crisci A, Trovato C
Boll Soc Ital Biol Sper. 1981 Jan 15;57(1):86-92.
The effects of cimetidine on experimental stress, induced by a long time fast and pylorus ligature, in male albino rats were investigated. The drug at the dose of 30 mg/kg was administered i.m. just after the operation and 12 h later. To evaluate the interference of cimetidine on the hypothalamo-hypophyseal-adrenal axis were dosed, in the rat, the level of adrenal ascorbic acid and cholesterol as well as corticosterone plasma levels. The results seem to suggest that cimetidine, in this experiment, is unable to modify stress induced changes.
研究了西咪替丁对雄性白化病大鼠因长时间禁食和幽门结扎诱导的实验性应激的影响。在手术后立即及12小时后，以30mg/kg的剂量肌肉注射该药物。为评估西咪替丁对下丘脑-垂体-肾上腺轴的干扰，测定了大鼠肾上腺中抗坏血酸和胆固醇水平以及血浆皮质酮水平。结果似乎表明，在本实验中，西咪替丁无法改变应激诱导的变化。
