Svensjö E
Prostaglandins Med. 1978 Nov;1(5):397-410. doi: 10.1016/0161-4630(78)90126-x.
The hamster cheek pouch prepared for intravital observations on macromolecular permeability with fluorescein labelled dextran was used in four series of 5 hamsters each, all pretreated with indomethacin. Bradykinin, PGE1, PGE2 and PGF2alpha increased macromolecular leakage at postcapillary venules, and this leakage was reversible on removal of agent. A linear relation was found between the logarithmic value of dose of bradykinin and the mean number of leakage sites. No tachyphylaxis to bradykinin was seen. The effect of either PGE1, PGE2 or PGF2alpha applied simultaneously with bradykinin was to significantly (p less than 0.05) potentiate the bradykinin response. Bradykinin and these prostaglandins appeared to have the same site of action for their effect of increasing permeability, e.g. the postcapillary venule.
用荧光素标记的右旋糖酐对仓鼠颊囊进行活体观察，以研究大分子通透性。在四个系列实验中，每个系列用5只仓鼠，所有仓鼠均预先用消炎痛处理。缓激肽、前列腺素E1、前列腺素E2和前列腺素F2α可增加毛细血管后微静脉处的大分子渗漏，去除药物后这种渗漏是可逆的。缓激肽剂量的对数值与渗漏部位的平均数量之间呈线性关系。未观察到对缓激肽的快速耐受现象。与缓激肽同时应用时，前列腺素E1、前列腺素E2或前列腺素F2α的作用是显著（p小于0.05）增强缓激肽反应。缓激肽和这些前列腺素在增加通透性的作用方面似乎具有相同的作用部位，如毛细血管后微静脉。
