Tweedy Jennifer H, Dvoriashyna Mariia, Crawshaw Jessica R, Overby Darryl R, Repetto Rodolfo, Roberts Paul A, Spelman Tamsin A, Stewart Peter S, Foss Alexander J E
Department of Mathematical Sciences, University of Bath, Claverton Down, Bath, United Kingdom.
https://orcid.org/0000-0002-0084-2465.
Invest Ophthalmol Vis Sci. 2025 Apr 1;66(4):75. doi: 10.1167/iovs.66.4.75.
To develop a mathematical model of the unconventional outflow pathway.
The unconventional pathway is modeled as having two key components: the uveo-vortex and the trans-scleral pathways. The uveo-vortex pathway is modeled using Starling's law and the trans-scleral flow using predominately hydrostatic forces. We include transcytosis from the choriocapillaris (CC) and collapsibility of the suprachoroidal space (SCS) as particular features. There is considerable uncertainty in a number of model parameter values, and we identify the most significant ones using sensitivity analysis.
The model successfully generates a fluid flow from anterior to posterior in the choroidal tissue and the SCS, which also demonstrates many of the known physiological features, including the insensitivity of the unconventional flow to fluctuations in the IOP, albumin removal by the trans-scleral flow, and the CC as a net absorber of fluid from, and supplier of albumin to, the choroidal tissue. The model supports the two previously proposed mechanisms of the action of prostaglandin F2α analogues.
We have developed a theoretical model of the unconventional aqueous outflow pathway that successfully captures its physiological features and elucidates the actions of prostaglandin F2α analogues and other drugs.
建立非常规流出途径的数学模型。
将非常规途径建模为具有两个关键组成部分：葡萄膜-涡静脉途径和经巩膜途径。葡萄膜-涡静脉途径采用斯塔林定律建模，经巩膜流动主要采用流体静力建模。我们将脉络膜毛细血管的穿胞作用和脉络膜上腔的可塌陷性作为特殊特征纳入模型。许多模型参数值存在相当大的不确定性，我们通过敏感性分析确定了最重要的参数值。
该模型成功地在脉络膜组织和脉络膜上腔中产生了从前向后的流体流动，这也展示了许多已知的生理特征，包括非常规流动对眼压波动不敏感、经巩膜流动清除白蛋白，以及脉络膜毛细血管作为脉络膜组织的液体净吸收器和白蛋白供应者。该模型支持了先前提出的前列腺素F2α类似物作用的两种机制。
我们建立了一个非常规房水流出途径的理论模型，该模型成功地捕捉了其生理特征，并阐明了前列腺素F2α类似物和其他药物的作用。
