Burnazian R A, Kanaian A S, Megrabian V I
Biull Eksp Biol Med. 1981 Mar;91(3):288-90.
Increased vascular permeability of the mesentery was revealed in rats with experimental pancreatitis in the stage of pancreonecrosis with hemorrhagic component. This circumstance is related to a great extent to the release of biogenic amines, histamine and serotonine, from mast cells of the "microregion" and to the diminution of the amount of tissue eosinophils, an antihistamine link in the permeability control. Application of sodium thiosulfate improved vascular permeability, normalized the content of biogenic amines in mast cells and preserved the amount of eosinophils in the mesentery because of the protective effect of the drug on the pancreas.
在伴有出血成分的胰腺坏死阶段的实验性胰腺炎大鼠中，发现肠系膜血管通透性增加。这种情况在很大程度上与“微区”肥大细胞释放生物胺、组胺和5-羟色胺有关，也与组织嗜酸性粒细胞数量减少有关，嗜酸性粒细胞是通透性控制中的一种抗组胺环节。由于硫代硫酸钠对胰腺的保护作用，应用硫代硫酸钠可改善血管通透性，使肥大细胞中生物胺含量正常化，并维持肠系膜中嗜酸性粒细胞数量。
