[Changes in vascular permeability and the state of mesenteric mast cells in acute experimental pancreatitis and following treatment with sodium thiosulfate].

Increased vascular permeability of the mesentery was revealed in rats with experimental pancreatitis in the stage of pancreonecrosis with hemorrhagic component. This circumstance is related to a great extent to the release of biogenic amines, histamine and serotonine, from mast cells of the "microregion" and to the diminution of the amount of tissue eosinophils, an antihistamine link in the permeability control. Application of sodium thiosulfate improved vascular permeability, normalized the content of biogenic amines in mast cells and preserved the amount of eosinophils in the mesentery because of the protective effect of the drug on the pancreas.