Login I S, MacLeod R M
Brain Res. 1981 Jan 5;204(1):79-85. doi: 10.1016/0006-8993(81)90653-3.
Anterior pituitary glands from normal untreated rats synthesize and release the hormone prolactin (Prl) during incubation under in vitro conditions. Addition of dopamine (DA) greatly inhibits the release of Prl and to a lesser extent reduces Prl synthesis. When pituitary glands are incubated in the presence of reserpine, there is a similar significant dose-related inhibition of Prl release. This effect persists even in the presence of a DA antagonist (haloperidol) and after the depletion of hypothalamic amines by in vivo treatment with reserpine. Reserpine in vitro also inhibits release of newly synthesized growth hormone from the pituitary glands of male rats; however, this is not observed when female rats are studied. We conclude that the direct effect of reserpine to inhibit Prl release is apparently independent of any interaction with catecholamine systems and is mediated by other, presently undefined mechanisms.
在体外培养条件下，来自未接受处理的正常大鼠的垂体前叶会合成并释放催乳素（Prl）。添加多巴胺（DA）会极大地抑制Prl的释放，并且在较小程度上减少Prl的合成。当垂体在利血平存在的情况下进行培养时，会出现类似的与剂量相关的显著Prl释放抑制。即使存在DA拮抗剂（氟哌啶醇）以及在体内用利血平处理使下丘脑胺类耗竭后，这种效应仍然持续。利血平在体外也会抑制雄性大鼠垂体中新合成的生长激素的释放；然而，在研究雌性大鼠时未观察到这种情况。我们得出结论，利血平抑制Prl释放的直接作用显然独立于与儿茶酚胺系统的任何相互作用，并且是由目前尚未明确的其他机制介导的。
