Madjerek Z S, Smit-Vis J H
Acta Morphol Neerl Scand. 1977 Feb;15(1):65-74.
Six synthetic steroids were tested subcutaneously in a new bio-assay for short- and long-lasting progestational activity, using traumatic deciduoma production in immature female rats. As reference standard, a daily subcutaneous dose of 0.25 mg progesterone regularly induced a distinct deciduomagenic effect. A single dose of 12.5 mg of progesterone showed a prolonged activity. Medroxyprogesterone acetate showed a distinct deciduomagenic effect at the 0.05 mg daily s.c. dose level; a distinct prolonged effect was induced with a single s.c. injection of 0.5 mg. 16alpha-Aethylprogesterone induced regularly decidual reaction at the 0.1 mg s.c. dose level, it showed prolonged activity at the 0.25 mg dose level. The daily threshold dose for chlormadinone acetate was 0.25 mg; prolonged activity was shown with 2.5 mg. The daily threshold dose for duphaston is between 0.5 mg and 1.0 mg. A single s.c. dose of as much as 20.0 mg of 17alpha- hydroxyprogesterone caproate did not have a deciduomagenic effect.
在一项针对短效和长效孕激素活性的新生物测定中，采用未成熟雌性大鼠创伤性蜕膜瘤生成法，对六种合成类固醇进行了皮下注射测试。作为参考标准，每日皮下注射0.25毫克孕酮可定期诱导出明显的蜕膜瘤生成效应。单次注射12.5毫克孕酮显示出延长的活性。醋酸甲羟孕酮在每日皮下注射剂量为0.05毫克时显示出明显的蜕膜瘤生成效应；单次皮下注射0.5毫克可诱导出明显的延长效应。16α-乙基孕酮在皮下注射剂量为0.1毫克时可定期诱导蜕膜反应，在剂量为0.25毫克时显示出延长的活性。醋酸氯地孕酮的每日阈值剂量为0.25毫克；2.5毫克显示出延长的活性。地屈孕酮的每日阈值剂量在0.5毫克至1.0毫克之间。单次皮下注射高达20.0毫克的己酸羟孕酮没有蜕膜瘤生成效应。
