一种计算父权指数的新方法。

A new approach to the computation of indices of paternity.

作者信息

Minakata K, Asano M, Hattori H

出版信息

Comput Programs Biomed. 1980 Dec;12(2-3):191-200. doi: 10.1016/0010-468x(80)90065-3.

Abstract

This paper describes an algorithm to calculate several indices of paternity (combination frequency, paternity likelihood (Y/X) and paternity exclusion probability (E) for father-mother-child combination (trio) as well as father-child combination (duo). This program is written in FORTRAN IV and applicable to any kinds of blood group systems such as Rh and HLA. The characteristic points of the present method are as follows: First, the relation between genotypes and phenotypes is given in a straightforward way by introducing a translational matrix. Secondly, by a unit run on a computer, several indices of paternity are tabulated for all kinds of combinations of trio as well as duo. Finally, the efficiency of diagnosis of a certain system is listed by calculating the distribution of log (Y/X).

摘要

本文描述了一种算法，用于计算父母子组合（三联体）以及父子组合（二联体）的几个亲权指数（组合频率、亲权似然率（Y/X）和亲权排除概率（E））。该程序用FORTRAN IV编写，适用于任何血型系统，如Rh和HLA。本方法的特点如下：第一，通过引入一个转换矩阵，以直接的方式给出基因型和表型之间的关系。第二，通过在计算机上进行一次单元运算，为三联体以及二联体的所有组合列出几个亲权指数。最后，通过计算log（Y/X）的分布列出某一系统的诊断效率。