兔胃血管中的组胺H1和H2受体。

Histamine H1- and H2-receptors in the gastric vasculature of the rabbit.

作者信息

Curwain B P, Turner N C

出版信息

Eur J Pharmacol. 1981 May 22;71(4):515-9. doi: 10.1016/0014-2999(81)90199-0.

Abstract

The histamine receptors in the rabbit blood perfused gastric vasculature were analysed pharmacologically. Histamine elicited a monophasic increase in perfusion pressure which was antagonized by mepyramine and enhanced by metiamide. The maximum observed response was enhanced by metiamide to that produced by a specific H1-receptor agonist. It is concluded that the gastric vasculature responds to histamine with an H1-receptor mediated vasoconstriction and an H2-receptor mediated dilatation. In this preparation the H1-effect predominates in response to injection of histamine.

摘要

对兔血液灌注的胃血管系统中的组胺受体进行了药理学分析。组胺引起灌注压单相升高，该升高被美吡拉敏拮抗，被甲硫米特增强。甲硫米特使观察到的最大反应增强至特定H1受体激动剂所产生的反应水平。得出的结论是，胃血管系统对组胺的反应是由H1受体介导的血管收缩和H2受体介导的血管舒张。在该制备中，对组胺注射的反应中H1效应占主导。