甲基乙二醛对3-磷酸甘油醛脱氢酶的失活作用研究。
Studies on the inactivation of glyceraldehyde-3-phosphate dehydrogenase by methylglyoxal.
作者信息
Leoncini G, Maresca M, Ronchi S, Bonsignore A
出版信息
Experientia. 1981 May 15;37(5):443-4. doi: 10.1007/BF01986121.
PMID:7250305
Abstract
Glyceraldehyde-3-P dehydrogenase (E.C. 1.2.1.12) from rabbit muscle is rapidly inactivated by methylglyoxal following pseudo first-order kinetics. Substrate, as well as inorganic phosphate, affords protection, whereas NAD+ is ineffective. The arginine residue implicated in the reaction is probably the anion binding site of the phosphate group of the substrate.
摘要
来自兔肌肉的甘油醛-3-磷酸脱氢酶（E.C. 1.2.1.12）在假一级动力学条件下会被甲基乙二醛迅速灭活。底物以及无机磷酸盐能提供保护作用，而NAD⁺则无效。反应中涉及的精氨酸残基可能是底物磷酸基团的阴离子结合位点。
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