Schweppe K W, Dmowski W P, Wynn R M
Fertil Steril. 1981 Jul;36(1):20-6. doi: 10.1016/s0015-0282(16)45612-8.
Electron microscopic examinations were carried out on 29 representative endometriotic glands obtained from 16 biopsies. Patients with endometriosis diagnosed by laparoscopy and confirmed by laparoscopic biopsy prior to hormonal treatment received danazol, 800 mg daily. The tissue samples were obtained after 2, 4, and 6 months of usage of the drug to study the ultrastructural effect of this treatment. The glandular epithelium appeared to be arrested in what looked like the late proliferative stage of the normal menstrual cycle. The ciliated cells remained unchanged for the most part. The findings were correlated with possible effects of danazol on the target tissue, but caution is required in the interpretation of ultrastructural effects of steroids until detailed knowledge of the metabolic pathways is available.
对从16次活检中获取的29个具有代表性的子宫内膜异位腺体进行了电子显微镜检查。经腹腔镜检查诊断为子宫内膜异位症并在激素治疗前经腹腔镜活检确诊的患者，每天服用800毫克达那唑。在用药2、4和6个月后获取组织样本，以研究这种治疗的超微结构效应。腺上皮似乎停滞在正常月经周期的增殖晚期。纤毛细胞大部分保持不变。这些发现与达那唑对靶组织的可能作用相关，但在详细了解代谢途径之前，对类固醇超微结构效应的解释需要谨慎。
