Sicuteri F, Fanciullacci M, Michelacci S
Res Clin Stud Headache. 1978;6:19-33.
Central panalgesia is a syndrome which includes systemic pains of a central nature, usually classified as hysteria, fibrositis and masked depression. Exploration of the peripheral neuromuscular junctions (in the iris by pupillometry, and in veins by computerized venotest) indicates an increased monoamine receptor sensitivity. 5-HT vein sensitivity is particularly impressive (up to 1,000 times). In the vein there appears to be a decentralization supersensitivity, as it is extended to different monoamines (5-HT, dopamine, noradrenaline, tyramine). This type of supersensitivity is compatible with the theory of a deficiency of neurotransmitters at the level of the anti-nociceptive and integrated systems, with subsequent central and peripheral supersensitivity. A similar condition limited to the rostral section of the anti-nociceptive system is valid for the mechanism of idiopathic headache including migraine: central and peripheral supersensitivity to monoamines and opiates is also episodically observed in headache sufferers.
中枢性痛觉过敏是一种综合征，包括具有中枢性质的全身性疼痛，通常归类为癔症、纤维肌痛和隐匿性抑郁症。对外周神经肌肉接头的检测（通过瞳孔测量法检测虹膜，通过计算机静脉检测法检测静脉）表明单胺受体敏感性增加。5-羟色胺静脉敏感性尤其显著（高达1000倍）。在静脉中似乎存在一种去神经超敏反应，因为它扩展到了不同的单胺（5-羟色胺、多巴胺、去甲肾上腺素、酪胺）。这种超敏反应类型与抗伤害感受和整合系统水平上神经递质缺乏的理论相符，随后会出现中枢和外周超敏反应。局限于抗伤害感受系统头端部分的类似情况对于包括偏头痛在内的特发性头痛机制是有效的：在头痛患者中也会间歇性观察到对单胺和阿片类药物的中枢和外周超敏反应。
