Blaine E H, Dunlay M C
J Pharmacol Exp Ther. 1981 Aug;218(2):470-4.
Adult ewes were studied to determine the effects of barbiturate anesthesia on renal function and the natriuretic response to renal vasodilation by papaverine and acetylcholine. During a period of consciousness, renal blood flow, glomerular filtration rate, urinary Na excretion (UNaV) and arterial blood pressure were monitored. Renal blood flow was maximally increased by renal arterial infusion of papaverine or acetylcholine and changes in renal function were observed. The sheep were subsequently anesthetized and the experimental protocol was repeated. Barbiturate anesthesia resulted in statistically significant increases in glomerular filtration rate, UNaV and blood pressure. Calculated fractional Na excretion also increased significantly. During consciousness, maximal renal vasodilation by papaverine or acetylcholine did not increase UNaV or fractional Na excretion. During anesthesia, both papaverine and acetylcholine produced large increases in both UNaV and fractional Na excretion. These data indicate that renal vasodilation per se is not a sufficient condition to increase UNaV and suggest that barbiturate anesthetics can alter renal function in such a manner as to render drugs, which are not natriuretic during consciousness, effective natriuretic agents during anesthesia.
对成年母羊进行了研究，以确定巴比妥类麻醉对肾功能的影响，以及罂粟碱和乙酰胆碱引起的肾血管舒张对利钠反应的影响。在清醒期间，监测肾血流量、肾小球滤过率、尿钠排泄量（UNaV）和动脉血压。通过肾动脉输注罂粟碱或乙酰胆碱使肾血流量最大程度增加，并观察肾功能的变化。随后对绵羊进行麻醉，并重复实验方案。巴比妥类麻醉导致肾小球滤过率、UNaV和血压在统计学上显著升高。计算得出的钠排泄分数也显著增加。在清醒期间，罂粟碱或乙酰胆碱引起的最大程度肾血管舒张并未增加UNaV或钠排泄分数。在麻醉期间，罂粟碱和乙酰胆碱均使UNaV和钠排泄分数大幅增加。这些数据表明，肾血管舒张本身并非增加UNaV的充分条件，并提示巴比妥类麻醉剂可改变肾功能，使在清醒时无利钠作用的药物在麻醉期间成为有效的利钠剂。
