Goldberg O, Luini A, Teichberg V I
Neurosci Lett. 1981 May 6;23(2):187-91. doi: 10.1016/0304-3940(81)90038-0.
The effects of amino acid lactones chemically derived from the neuroexcitant kainic acid on the response of rat striatal slices to excitatory amino acids, were studied. These compounds antagonize to varying extents the effects of kainic acid and N-methyl-D-aspartic acid but have no effect on the responses to glutamic or quisqualic acid. Some of the lactones antagonize preferentially the effects of kainic acid. This study further confirms the existence of heterogenous populations of excitatory amino acid receptors in the rat striatum.
研究了从神经兴奋性物质海藻酸化学衍生而来的氨基酸内酯对大鼠纹状体切片对兴奋性氨基酸反应的影响。这些化合物在不同程度上拮抗海藻酸和N-甲基-D-天冬氨酸的作用，但对谷氨酸或喹啉酸的反应没有影响。一些内酯优先拮抗海藻酸的作用。这项研究进一步证实了大鼠纹状体中存在异质性的兴奋性氨基酸受体群体。
