多种二腺苷多磷酸对末端脱氧核苷酸转移酶的抑制作用。

Inhibition of terminal deoxynucleotidyltransferase by various diadenosine polyphosphates.

作者信息

Ono K, Iwata Y, Nakamura H, Matsukage A

出版信息

Nucleic Acids Symp Ser. 1980(8):s187-90.

Abstract

Terminal deoxynucleotidyltransferase (TdT) was found to be strongly inhibited by diadenosine 5',5"'-P1,P4-tetraphosphate (AP4A) while other mammalian DNA polymerases alpha, beta and gamma were neither inhibited nor activated by AP4A. Such inhibitory effect on TdT was also observed with a variety of diadenosine polyphosphates (APnA), n = 3-6) when TdT activity was assayed by determining incorporation of dCTP. Kinetic analysis revealed that the inhibition of TdT by APnA was due to competition with substrate deoxynucleoside triphosphate(s).

摘要

末端脱氧核苷酸转移酶（TdT）被发现受到5',5'''-P1,P4-四磷酸二腺苷（AP4A）的强烈抑制，而其他哺乳动物DNA聚合酶α、β和γ既不被AP4A抑制也不被其激活。当通过测定dCTP掺入来检测TdT活性时，在多种二腺苷多磷酸（APnA，n = 3 - 6）中也观察到了对TdT的这种抑制作用。动力学分析表明，APnA对TdT的抑制是由于与底物脱氧核苷三磷酸竞争所致。

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