Wagner J, Manthorpe R, Philip P, Frost F
Scand J Haematol. 1978 Oct;21(4):299-304. doi: 10.1111/j.1600-0609.1978.tb00368.x.
A 73-year-old man who had suffered for many years from psoriasis was treated with systemic psoralen and longwave ultraviolet light. After 1 year he developed a preleukaemic condition characterized by a refractory anaemia, a slight thrombocytopenia and a normo- to hypercellular bone marrow with an excess of myeloblasts. Karyotyping revealed an abnormal chromosome (12p-) and agar cultures of bone marrow showed moderate growth with a high cluster/colony ratio. He died 1 year later of renal failure precipitated by an acute pancreatitis. Owing to the possible causal relationship we would like to advise increased attention to the haematopoietic system of patients treated with psoralen.
一名患有银屑病多年的73岁男性接受了系统性补骨脂素和长波紫外线治疗。1年后，他出现了一种白血病前期状态，其特征为难治性贫血、轻度血小板减少以及骨髓细胞正常至增多，伴有过多的成髓细胞。核型分析显示一条异常染色体（12p-），骨髓琼脂培养显示生长适度，集簇/集落比值较高。1年后，他死于急性胰腺炎引发的肾衰竭。鉴于可能存在的因果关系，我们建议对接受补骨脂素治疗的患者的造血系统给予更多关注。
