吡唑并-[3,4-B]-吡啶衍生物的合成及生物学性质。II.
Synthesis and biological properties of pyrazo-[3,4-B]-pyridine derivatives. II.
作者信息
Kuczyński L, Mrozikiewicz A, Banaszkiewicz W, Poreba K
出版信息
Pol J Pharmacol Pharm. 1981 Jan-Feb;33(1):107-13.
PMID:7255276
Abstract
By aminoalkylation with diethylaminoethyl chloride of 3-hydroxypyrazo-[3,4-b]-pyridine 1 and its phenyl derivative 2 as well as 3-aminopyrazo-[3,4-b]-pyridine 7 and its phenyl derivative 8, basic ethers 5, 6 and aminoalkanoloamines 9 and 10 have been obtained. Compounds 5, 6 and 10 increased coronary blood flow of the isolated cat heart. At the concentration of 5 +/- 2 mg/ml shoved spasmolytic activity.
摘要
通过用3-羟基吡唑并[3,4-b]吡啶1及其苯基衍生物2以及3-氨基吡唑并[3,4-b]吡啶7及其苯基衍生物8与氯代二乙氨基乙醇进行氨基烷基化反应，得到了碱性醚5、6以及氨基链烷醇胺9和10。化合物5、6和10增加了离体猫心脏的冠脉血流量。在5±2毫克/毫升的浓度下显示出解痉活性。
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