Klingen G, Nyström S O
Scand J Thorac Cardiovasc Surg. 1978;12(3):221-7.
The haemodynamic effects of intravenous (i.v.) administration of ethanol were studied in two groups of patients--groups IV and V--during the first hours after aortic valve replacement. A group of seven patients, who underwent the same operation but were not treated with ethanol, served as controls (Klingen et al., 1978 c). The ethanol was given by continuous i.v. infusion. It was started after termination of bypass and was continued for 6 hours postoperatively. Group IV (9 patients) had a blood concentration of about 20 mmol/l. Group V (8 patients) had a blood concentration constant at 35-40 mmol/l. Groups IV and V differed from group III in their reactions in the following respects, and the differences may be attributed to the ethanol. In the former groups the arterial (systemic) blood pressure and total peripheral vascular resistance were lower (P less than 0.01 and P less than 0.001, respectively). Cardiac output was higher (P less than 0.05) and the arteriovenous oxygen difference lower (P less than 0.01) in group IV and V and increased at an early stage (P less than 0.01). The study shows that ethanol in blood concentrations of 20 and 35-40 mmol/l has approximately the same vasodilative effect, with no influence on the heart rate and no depressive effect on myocardial function; on the contrary this function tended to be stimulated at a blood concentration of 35-40 mmol/l.
在主动脉瓣置换术后的最初几个小时内，对两组患者（IV组和V组）进行了静脉注射乙醇的血流动力学效应研究。一组7例接受相同手术但未接受乙醇治疗的患者作为对照（Klingen等人，1978年c）。乙醇通过静脉持续输注给药。在体外循环结束后开始给药，并在术后持续6小时。IV组（9例患者）的血药浓度约为20 mmol/l。V组（8例患者）的血药浓度恒定在35 - 40 mmol/l。IV组和V组在以下方面的反应与III组不同，这些差异可能归因于乙醇。在前两组中，动脉（全身）血压和总外周血管阻力较低（分别为P < 0.01和P < 0.001）。IV组和V组的心输出量较高（P < 0.05），动静脉血氧差较低（P < 0.01），且在早期增加（P < 0.01）。该研究表明，血药浓度为20和35 - 40 mmol/l的乙醇具有大致相同的血管舒张作用，对心率无影响，对心肌功能无抑制作用；相反，在血药浓度为35 - 40 mmol/l时，该功能有被刺激的趋势。
