Terlizzi N, Carrozzo M, D'Amore M, Martiradonna A, Muratore M
Rev Rhum Mal Osteoartic. 1981 May;48(5):419-22.
In this study the authors developed new technics of study of duodenal absorption of calcium in rats: atomic absorption spectrophotometry, and dialysis to equilibrium. We considered that the main factors necessary for evaluation of duodenal absorption of calcium are the serum calcium, the calcium and alkaline phosphatase present in the duodenal cells and the calcium-binding proteins. The authors demonstrate that these factors are highest in rats treated with 25 OHD3 and norandrostenolone decanoate, than in control rats. In rats treated with diphosphonate, on the contrary, they obtained a reduction in the values of calcium and alkaline phosphatase contained in the duodenal cells.
在本研究中,作者开发了大鼠十二指肠钙吸收研究的新技术:原子吸收分光光度法和平衡透析法。我们认为评估十二指肠钙吸收所需的主要因素是血清钙、十二指肠细胞中存在的钙和碱性磷酸酶以及钙结合蛋白。作者证明,这些因素在接受25-OHD3和癸酸诺龙治疗的大鼠中比对照大鼠中更高。相反,在用双膦酸盐治疗的大鼠中,他们发现十二指肠细胞中钙和碱性磷酸酶的值降低。