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[以正常冠状动脉痉挛作为反复心室颤动的病因]

[Coronary artery spasms with normal coronary arteries as the cause of recurrent ventricular fibrillations].

作者信息

Hess O M, Graf C, Frey R, Dettli R, Siegenthaler W

出版信息

Schweiz Med Wochenschr. 1981 May 23;111(21):755-8.

PMID:7256231
Abstract

Coronary arterial spasms are thought to be responsible for acute myocardial infarction in some patients with normal coronary arteries. A report is presented on a patient with a history of Prinzmetal angina pectoris involving ST-segment elevations in the electrocardiogram and recurrent ventricular fibrillation. Selective coronary arteriography revealed normal coronary arteries. Administration of nifedipin and isosorbide dinitrate brought about prompt relief of pain. One year after cardiac catheterization the patient developed recurrent ventricular arrhythmias when administration of nifedipin was discontinued. It is concluded that coronary arterial spasms may occur in patients with normal coronaries and may cause transient myocardial ischemia with severe ventricular arrhythmias. A history of Prinzmetal angina pectoris is usually present and medical treatment consists in administration of nifedipin and isosorbide dinitrate.

摘要

冠状动脉痉挛被认为是一些冠状动脉正常的患者发生急性心肌梗死的原因。本文报告了一例有变异型心绞痛病史的患者,其心电图出现ST段抬高并反复发作心室颤动。选择性冠状动脉造影显示冠状动脉正常。给予硝苯地平和硝酸异山梨酯后疼痛迅速缓解。心脏导管检查一年后,停用硝苯地平后患者出现反复发作的室性心律失常。结论是,冠状动脉正常的患者可能发生冠状动脉痉挛,并可能导致短暂性心肌缺血伴严重室性心律失常。患者通常有变异型心绞痛病史,药物治疗包括给予硝苯地平和硝酸异山梨酯。

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