Palumbo N E, Desowitz R S, Perri S F
Tropenmed Parasitol. 1981 Jun;32(2):115-8.
The severity of the adverse reaction, as assessed by clinical, haematological, and biochemical abnormalities, following treatment of Dirofilaria immitis-infected dogs with diethylcarbamazine (DEC) was found to be related to the level of microfilaraemia. The magnitude of change in the blood constituents studied was proportional to the severity of the side reaction. The most notable alterations in dogs experiencing a moderate or severe adverse reaction were a decrease in platelet numbers and fibrinogen level, a rise in serum transaminases, and the appearance of fibrin monomers. The practical value of qualitatively and quantitatively characterizing the post DEC adverse reaction is discussed.
用乙胺嗪（DEC）治疗感染犬恶丝虫的犬后，通过临床、血液学和生化异常评估的不良反应严重程度与微丝蚴血症水平有关。所研究的血液成分变化幅度与副作用的严重程度成正比。经历中度或重度不良反应的犬最显著的变化是血小板数量和纤维蛋白原水平降低、血清转氨酶升高以及纤维蛋白单体出现。文中讨论了定性和定量表征DEC治疗后不良反应的实际价值。
