氢氯噻嗪所致急性免疫性血管内溶血

Acute immune intravascular hemolysis due to hydrochlorothiazide.

作者信息

Garratty G, Houston M, Petz L D, Webb M

出版信息

Am J Clin Pathol. 1981 Jul;76(1):73-8. doi: 10.1093/ajcp/76.1.73.

DOI:10.1093/ajcp/76.1.73

Abstract

Acute near-fatal intravascular hemolysis and renal failure developed in a patient after he had ingested 15 to 20 tablets of both methyldopa (Aldomet) nd hydrochlorothiazide (HydroDiuril). Serologic test results were inconsistent with those associated with methyldopa-induced hemolytic anemia and suggested that hemolysis was caused by hydrochlorothiazide antibodies reacting by an immune complex mechanism.

摘要

一名患者在摄入15至20片甲基多巴（爱道美）和氢氯噻嗪（双氢克尿噻）后出现急性近乎致命的血管内溶血和肾衰竭。血清学检测结果与甲基多巴诱导的溶血性贫血不相符，提示溶血是由氢氯噻嗪抗体通过免疫复合物机制反应所致。