Sørensen S S
Am J Obstet Gynecol. 1981 Jul 15;140(6):636-44. doi: 10.1016/0002-9378(81)90196-4.
Because a causal relationship was suspected between mild müllerian anomalies and oligomenorrhea-amenorrhea, the hysterosalpingograms of 134 consecutive infertility patients were reviewed. The review was blind with respect to menstrual pattern and other data. Mild müllerian anomalies of the uterus were exhibited in 21.6%; and among them, 58.6% had oligomenorrhea or amenorrhea. By comparison, oligomenorrhea or amenorrhea was found in only 19.6% of the remainder of infertility patients with normal uterine cavities (p less than 0.01). The association between mild müllerian anomalies and oligomenorrhea is further confirmed by the latter being idiopathic in 82.4% of these patients, in contrast to 30% of the group with normal uteri (p less than 0.01). Perusal of the literature shows that this relationship does not appear to have been substantiated previously, but occasionally it has been mentioned as a chance coincidence. On the basis of the patient's hormonal status and studies of the literature, the author advances the hypothesis of a defect in the steroid receptor proteins in the congenitally somewhat deformed uterus, in explanation of these patients' oligomenorrhea. The conclusion is that there must be a hitherto unheeded syndrome of fairly mild müllerian anomalies and eugonadotropic oligomenorrhea with demonstrable ovulation in infertile or low-fertility women. Perhaps, an increased tendency to abortion in the first or second trimester is another characteristic of this syndrome.
由于怀疑轻度苗勒管异常与月经过少-闭经之间存在因果关系，我们回顾了134例连续不孕患者的子宫输卵管造影。回顾过程对月经模式和其他数据采用盲法。子宫轻度苗勒管异常的发生率为21.6%；其中，58.6%有月经过少或闭经。相比之下，子宫腔正常的其余不孕患者中，月经过少或闭经的发生率仅为19.6%（p<0.01）。轻度苗勒管异常与月经过少之间的关联进一步得到证实，因为在这些患者中，82.4%的月经过少或闭经是特发性的，而子宫正常组这一比例为30%（p<0.01）。查阅文献表明，这种关系以前似乎没有得到证实，但偶尔被提及为一种偶然巧合。基于患者的激素状态和文献研究，作者提出先天性轻度畸形子宫中类固醇受体蛋白存在缺陷的假说，以解释这些患者的月经过少。结论是，在不孕或低生育力女性中，一定存在一种迄今未被重视的综合征，即相当轻度的苗勒管异常和有可证实排卵的正常促性腺激素性月经过少。也许，孕早期或孕中期流产倾向增加是该综合征的另一个特征。
