Williams J C, Knox J W, Baumann B A, Snider T G, Hoerner T J
Am J Vet Res. 1981 Feb;42(2):318-21.
Albendazole was evaluated for its efficacy against inhibited early 4th-stage larvae of Ostertagia ostertagi for the 3rd consecutive year (April 1979) in naturally infected yearling beef cattle. Mean numbers of O ostertagi developmental stages in 10 nontreated controls were: adults, 11,485; developing 4th-stage larvae, 1,370; and early 4th-stage larvae, 51,500. The mean proportion of inhibited early 4th-stage larvae was 76.8%. Small numbers of Haemonchus sp and Trichostrongylus axei were uniformly present in the controls. At a dosage level of 7.5 mg/kg of body weight in a group of 10 cattle, the percentage of reduction in comparison with controls was: O ostertagi adults, 93.5; developing 4th-stage larvae, 53.4; developing 4th-stage larvae, 30.8. Percentage of reduction against Haemonchus sp and T axei adults was 94.5 and 100.0, respectively. At the larger dosage of 10.0 mg/kg in 10 cattle, percentage of reduction was: O ostertagi adults, 94.8; developing 4th-stage larvae, 18.6. Percentage of reduction against Haemonchus sp and T axei adults was 100.0 for both species. Considerable variability of efficacy against inhibited larvae, as well as developing 4th-stage larvae in half of the animals of each treatment group, was responsible for the poor reductions. Clinical signs of toxicosis were not observed after administration of albendazole.
连续第三年（1979年4月）对自然感染的一岁肉牛进行试验，评估阿苯达唑对奥斯特他线虫抑制性第四期幼虫早期阶段的疗效。10头未治疗对照牛体内奥斯特他线虫发育阶段的平均数量为：成虫11,485条；发育中的第四期幼虫1,370条；第四期幼虫早期51,500条。抑制性第四期幼虫早期的平均比例为76.8%。对照牛体内均有少量血矛线虫属和艾氏毛圆线虫。在一组10头牛中，按7.5毫克/千克体重的剂量给药，与对照相比的减少百分比为：奥斯特他线虫成虫93.5%；发育中的第四期幼虫53.4%；第四期幼虫早期30.8%。对血矛线虫属和艾氏毛圆线虫成虫的减少百分比分别为94.5%和100.0%。在10头牛中按10.0毫克/千克的较大剂量给药，减少百分比为：奥斯特他线虫成虫94.8%；发育中的第四期幼虫18.6%。对血矛线虫属和艾氏毛圆线虫成虫的减少百分比均为100.0%。每个治疗组半数动物中，对抑制性幼虫以及发育中的第四期幼虫的疗效差异很大，导致减少效果不佳。给予阿苯达唑后未观察到中毒的临床症状。
