Pratt S E, Brauer M A, Corwin R M
Am J Vet Res. 1981 May;42(5):871-2.
The relative efficacies of pyrantel tartrate and of pyrantel citrate against Oesophagostomum sp in swine were evaluated in a controlled-critical study and the efficacy of pyrantel citrate in a field trial. In the controlled-critical study, pigs naturally infected with Oesophagostomum dentatum were either not treated or were treated with pyrantel citrate or pyrantel tartrate at a dosage of 510 mg of free pyrantel base/kg of feed. Six days later, the pigs were necropsied, adult O dentatum was recovered and counted, and fecal samples were examined for helminth eggs. The efficacies of pyrantel citrate and pyrantel tartrate were each 100% based on fecal egg counts and numbers of adults at necropsy. The field trial was conducted in a similar manner except that pyrantel citrate only was tested against a control group on the basis of fecal egg counts made both at the beginning and at the termination of the trial. In this study pyrantel citrate was found to reduce Oesophagostomum sp egg counts by 89.4%.
在一项对照关键研究中评估了酒石酸噻嘧啶和枸橼酸噻嘧啶对猪食道口线虫的相对疗效，并在一项田间试验中评估了枸橼酸噻嘧啶的疗效。在对照关键研究中，将自然感染有齿食道口线虫的猪不进行治疗，或以510毫克游离噻嘧啶碱/千克饲料的剂量用枸橼酸噻嘧啶或酒石酸噻嘧啶进行治疗。六天后，对猪进行剖检，回收并计数成年有齿食道口线虫，并检查粪便样本中的蠕虫卵。基于粪便虫卵计数和剖检时成虫数量，枸橼酸噻嘧啶和酒石酸噻嘧啶的疗效均为100%。田间试验以类似方式进行，只是仅根据试验开始时和结束时的粪便虫卵计数，将枸橼酸噻嘧啶与一个对照组进行比较测试。在这项研究中，发现枸橼酸噻嘧啶可使食道口线虫属虫卵计数减少89.4%。
