Kotlyarov E V, Elson J D, Quaife M A
Ann Clin Lab Sci. 1981 Mar-Apr;11(2):173-9.
The findings of 49 67Ga citrate scans were correlated with all clinical information obtained by other diagnostic modalities in untreated and treated patients with histopathologically proven Hodgkin's disease (539 sites). Eleven nodal and extranodal sites were analyzed in terms of sensitivity, specificity, accuracy and, subsequently, by calculations of the posterior probability for the presence of disease at positive and negative sites by scan using Bayes' theorem. Lowest posterior probabilities for the presence of disease at positive sites were seen in lung parenchyma (66 percent) and spleen (67 percent) in untreated patients and for treated patients in adbominal nodes an inguinal nodes (both 66 percent), whereas the scan was a good method for detecting Hodgkin's disease at all other sites where posterior probabilities were near 100 percent. Figures for the posterior probability of disease at negative sites by scan showed it was a good modality for ruling out Hodgkin's involvement in axillary nodes, perihilar nodes, lung parenchyma, inguinal nodes, and bone marrow (all less than 10 percent); however, it was not as satisfactory in ruling out disease in untreated cervical nodes (20 percent), supraclavicular nodes (11 percent), and especially in the intraabdominal sites of spleen (35 percent), abdominal nodes (33 percent), and periaortic nodes (27 percent).
对49例经病理组织学证实为霍奇金病的未治疗和已治疗患者（共539个部位）进行了枸橼酸镓67扫描，并将扫描结果与通过其他诊断方法获得的所有临床信息进行了对比。对11个淋巴结和结外部位进行了敏感性、特异性、准确性分析，随后，利用贝叶斯定理计算扫描呈阳性和阴性部位存在疾病的后验概率。在未治疗患者中，肺实质（66%）和脾脏（67%）扫描呈阳性部位存在疾病的后验概率最低；在已治疗患者中，腹主动脉旁淋巴结和腹股沟淋巴结扫描呈阳性部位存在疾病的后验概率最低（均为66%），而在所有其他后验概率接近100%的部位，扫描是检测霍奇金病的良好方法。扫描呈阴性部位存在疾病的后验概率数据表明，扫描是排除腋窝淋巴结、肺门周围淋巴结、肺实质、腹股沟淋巴结和骨髓霍奇金累及的良好方法（均低于10%）；然而，在排除未治疗的颈部淋巴结（20%）、锁骨上淋巴结（11%），尤其是脾脏（35%）、腹主动脉旁淋巴结（33%）和主动脉周围淋巴结（27%）等腹内部位的疾病方面，扫描并不令人满意。
