Liesiene V, Adrien J, Benoit O
Arch Ital Biol. 1981 May;119(2):125-38.
Bilateral electrocoagulation of the locus coeruleus (LC) were performed in 8 cats, in order to study the effects on the heart rate modulation during sleep. In 4 cats the lesions were restricted to the posterior part of LC: they induced a permanent tachycardia in all states, and a reduction of the phasic changes during paradoxical sleep (PS), while the state-linked modulations remained similar to those of controls. In another group of 4 cats, lesions extended rostrally to the anterior LC. They induced a bradycardia evidenced mostly during PS. Phasic changes persisted though the tachycardic component was greatly reduced. The state-linked modulations were opposite to those of controls: increase during transition from slow waves sleep (SWS) to PS and decrease during PS. No recovery trend was observed within the 3 weeks post-lesion experimental period. These data are discussed in relation to the well-known parasympathetic and sympathetic regulations of the heart rate, with special attention to the changes observed during transition from slow waves sleep (SWS) to PS and during the first minute of PS. This period corresponds to a shift in the balance of tonic and phasic influences.
为了研究对睡眠期间心率调节的影响，对8只猫进行了双侧蓝斑（LC）电凝。在4只猫中，损伤局限于蓝斑后部：它们在所有状态下均诱发永久性心动过速，并减少了异相睡眠（PS）期间的相位变化，而与状态相关的调节与对照组相似。在另一组4只猫中，损伤向前延伸至蓝斑前部。它们主要在异相睡眠期间诱发心动过缓。尽管心动过速成分大大减少，但相位变化仍然存在。与状态相关的调节与对照组相反：从慢波睡眠（SWS）转变为异相睡眠期间增加，而异相睡眠期间减少。在损伤后的3周实验期内未观察到恢复趋势。结合众所周知的心率副交感神经和交感神经调节对这些数据进行了讨论，特别关注从慢波睡眠（SWS）转变为异相睡眠期间以及异相睡眠的第一分钟内观察到的变化。这一时期对应于紧张性和相位性影响平衡的转变。
